rs121434527
A SNP in the ACTA2 gene on chromosome 10. Its most notable genotype is C;T: Familial thoracic aortic aneurysms and dissections (FTAAD)
- Gene
- ACTA2
- Location
- Chr 1088,939,542 (GRCh38)
- Highest magnitude
- 6.5Very important
- Tested on
- AncestryDNA
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
- C;TMost notableBadFamilial thoracic aortic aneurysms and dissections (FTAAD)
- C;CGoodcommon in clinvar
SNPedia records rs121434527 on the minus strand: (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Other ACTA2 SNPs
- rs121434528A;GThoracic aortic aneurysm and dissection (TAAD) mutationVery important
- rs112602953C;TFamilial thoracic aortic aneurysms and dissections (FTAAD)Very important
- rs112901682C;GFamilial thoracic aortic aneurysms and dissections (FTAAD)Very important
- rs121434526A;GFamilial thoracic aortic aneurysms and dissections (FTAAD)Very important
- rs387906592C;TFamilial thoracic aortic aneurysms and dissections (FTAAD)Very important
Source and license
Adapted from rs121434527 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.