rs121907964
A SNP in the HEXA-AS1 gene on chromosome 15. Its most notable genotype is T;T: Tay-Sachs disease (predicted)
- Gene
- HEXA-AS1
- Location
- Chr 1572,375,895 (GRCh38)
- Highest magnitude
- 8.8Very important
- Tested on
- AncestryDNA
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
- T;TMost notableBadTay-Sachs disease (predicted)
- C;TBadCarrier of a Tay-Sachs mutation
- C;CGoodcommon in clinvar
SNPedia records rs121907964 on the minus strand: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Conditions, medicines and genes
Notes
From SNPedia
Notes
23andMe name: i5004832
T;T
see discussion at Tay-Sachs disease.
C;T
Unaffected in absence of a second HEXA gene mutation; see discussion at Tay-Sachs disease.
Source and license
Adapted from rs121907964 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.