rs121908073
A SNP in the TMC1 gene on chromosome 9. Its most notable genotype is C;T: Carrier of a nonsyndromic deafness mutation
- Gene
- TMC1
- Location
- Chr 972,694,578 (GRCh38)
- Highest magnitude
- 3.0Important
- Tested on
- AncestryDNA
- Minor allele frequency
- <1%
Genotypes
As shown in 23andMe and AncestryDNA files.
- C;CGoodcommon in clinvar
- C;TMost notableBadCarrier of a nonsyndromic deafness mutation
On SNPedia: (C;C), (C;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Other TMC1 SNPs
- rs121908072A;GDFNA36 deafness (predicted)Very important
- rs775428246C;GDFNA36 deafness (predicted)Very important
- rs786201027A;TDFNA36 deafness (predicted)Very important
- rs1387886173A;GDFNA36 deafness (predicted)Very important
- rs121908074A;GCarrier of a DFNB7/11 deafness mutationImportant
- rs121908076C;TCarrier of a DFNB7/11 deafness mutationImportant
- rs138527651C;TCarrier of a DFNB7/11 deafness mutationImportant
- rs151001642C;TCarrier of a DFNB7/11 deafness mutationImportant
Notes
From SNPedia
Notes
aka c.100C>T (p.Arg34Ter or R34X) 23andMe name: i5003572
C;T
Unaffected in absence of a second TMC1 gene mutation
Source and license
Adapted from rs121908073 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.