rs121908345

A SNP in the MLC1 gene on chromosome 22. Its most notable genotype is A;G: Carrier of a mutation for megalencephalic leukoencephalopathy with subcortical cysts

Gene
MLC1
Location
Chr 2250,080,391 (GRCh38)
Highest magnitude
3.0Important
Tested on
AncestryDNA

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. G;GGoodcommon in clinvarTypical · 0.0
  2. A;GMost notableBadCarrier of a mutation for megalencephalic leukoencephalopathy with subcortical cystsImportant · 3.0

SNPedia records rs121908345 on the minus strand: (C;C), (C;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Notes

From SNPedia

Notes

aka c.274C>T (p.Pro92Ser or P92S)

A;G

Unaffected in absence of a second MLC1 gene mutation

Source and license

Adapted from rs121908345 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.