rs121908377
A SNP in the FOXP2 gene on chromosome 7. Its most notable genotype is A;G: speech and other processing issues
- Gene
- FOXP2
- Location
- Chr 7114,662,075 (GRCh38)
- Highest magnitude
- 3.0Important
- Tested on
- AncestryDNA
Genotypes
As shown in 23andMe and AncestryDNA files.
- A;GMost notableBadspeech and other processing issues
- G;GGoodcommon in clinvar
On SNPedia: (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Other FOXP2 SNPs
- rs121908378C;Tspeech and other processing issuesImportant
- rs786200976-;Aspeech and other processing issues possibleImportant
- rs879253770-;ACAACAGCAGCAspeech and other processing issues possibleImportant
- rs879253771-;CAspeech and other processing issues possibleImportant
- rs879253772C;Tspeech and other processing issues possibleImportant
- rs1064793842-;Gspeech and other processing issues possibleImportant
- rs10227893T;Tcommon in complete genomicsTypical
Notes
From SNPedia
Notes
rs121908377, also known as Arg553His or R553H, is a G-to-A transition in exon 14 of the FOXP2 gene. As a dominant mutation, rs121908377(G) has been linked to developmental verbal dyspraxia. The associated disorder is known as Speech-language disorder-1 or SPCH1.
A;G
This rare, dominant mutation is linked to verbal dyspraxia.
Source and license
Adapted from rs121908377 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.