rs121908428

A SNP in the SLC12A6 gene on chromosome 15. Its most notable genotype is A;A: ACCPN neurological disorder

Gene
SLC12A6
Location
Chr 1534,243,993 (GRCh38)
Highest magnitude
6.0Very important
Tested on
AncestryDNA

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. G;GGoodcommon in clinvarTypical · 0.0
  2. A;GBadcarrier of an ACCPN neurological mutationImportant · 3.0
  3. A;AMost notableBadACCPN neurological disorderVery important · 6.0

SNPedia records rs121908428 on the minus strand: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Other SLC12A6 SNPs

All SLC12A6 SNPs

Notes

From SNPedia

Notes

rs121908428, also known as R675X, is a SNP in the SLC12A6 gene. The risk allele rs121908428(T) accounts for most of the ACCPN mutations seen in French-Canadian populations. Note that 23andMe reports this SNP from the opposite strand as dbSNP, so for their equivalent SNP, i5012575, the risk allele is (A).

A;A

ACCPN = Agenesis of the Corpus Callosum with Peripheral Neuropathy

Source and license

Adapted from rs121908428 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.