rs121908613

A SNP in the CYP7B1 gene on chromosome 8. Its most notable genotype is A;T: Carrier of a spastic paraplegia mutation

Gene
CYP7B1
Location
Chr 864,615,716 (GRCh38)
Highest magnitude
3.0Important
Tested on
AncestryDNA

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. A;TMost notableBadCarrier of a spastic paraplegia mutationImportant · 3.0
  2. A;AGoodcommon in clinvarTypical · 0.0

SNPedia records rs121908613 on the minus strand: (A;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Conditions, medicines and genes

Notes

From SNPedia

Notes

aka c. 825T>A, p.(Tyr275*) Massive sequencing of 70 genes reveals a myriad of missing genes or mechanisms to be uncovered in hereditary spastic paraplegia; implies the minor allele is a recessive mutation.

A;T

Unaffected in absence of a second CYP7B1 gene mutation; see publication cited via main rs-page.

Source and license

Adapted from rs121908613 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.