rs121908798
A SNP in the CFTR gene on chromosome 7. Its most notable genotype is G;TAT: carrier of a cystic fibrosis allele
- Gene
- CFTR
- Location
- Chr 7117,530,950 (GRCh38)
- Highest magnitude
- 3.0Important
- Tested on
- Not on consumer chips
Genotypes
As shown in 23andMe and AncestryDNA files.
On SNPedia: (G;TAT), (TAT;TAT). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Conditions, medicines and genes
Other CFTR SNPs
- i4000292D;Dcystic fibrosisVery important
- rs74551128A;ACystic fibrosisVery important
- rs113993960-;-Cystic Fibrosis; homozygote for delta F-508 mutationVery important
- rs199826652-;-Cystic Fibrosis; homozygote for delta F-508 mutationVery important
- i4000309A;ACystic FibrosisVery important
- i4000294A;ACystic FibrosisVery important
- i4000296T;TCystic FibrosisVery important
- i4000297A;ACystic FibrosisVery important
Notes
From SNPedia
Notes
Cystic fibrosis; c.325_327delTATinsG, Tyr109Glyfs There are seven 23andMe SNPs covering this replacement of 3 nucleotides (TAT) with a single nucleotide (G), but the company does not reveal which if any of the following SNPs from this region actually correspond to the known cystic fibrosis mutation at this position: i5010817, i5010818, i5010819, i5006106, i5010820, i5010821 and i5010822. Our guess is that it is i5010821; if you know if this is correct, please let us know.
G;TAT
Cystic fibrosis mutation carrier; unaffected unless CF mutation present on other copy of CF gene
Source and license
Adapted from rs121908798 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.