rs121908866

A SNP in the LOC101928462 gene on chromosome 14. Its most notable genotype is A;G: Carrier of a congenital hypothyroidism mutation; 3.3x higher risk for hypothyroidism

Gene
LOC101928462
Location
Chr 1481,143,695 (GRCh38)
Highest magnitude
3.0Important
Tested on
AncestryDNA

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;GMost notableBadCarrier of a congenital hypothyroidism mutation; 3.3x higher risk for hypothyroidismImportant · 3.0
  2. G;GGoodcommon in clinvarTypical · 0.0

On SNPedia: (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Other LOC101928462 SNPs

All LOC101928462 SNPs

Notes

From SNPedia

Notes

aka c.1637G>A (p.Trp546Ter or W546X) Inherited recessively, in Caucasians the W546X variant may be among one of the most common congenital hypothyroidism mutations; this variant is also reported as associated with a 3.3x higher risk of hypothyroidism. See also OMIM 603372.0010

A;G

Unaffected in absence of a second TSHR gene mutation; see links and text via main rs-page

Source and license

Adapted from rs121908866 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.