rs121909715

A SNP in the GSN gene on chromosome 9. Its most notable genotype is A;G: Familial amyloidosis; Meretoja syndrome

Gene
GSN
Location
Chr 9121,310,819 (GRCh38)
Highest magnitude
5.5Very important
Tested on
AncestryDNA

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;GMost notableBadFamilial amyloidosis; Meretoja syndromeVery important · 5.5
  2. G;GGoodcommon in clinvarTypical · 0.0

On SNPedia: (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Notes

From SNPedia

Notes

rs121909715, also known as c.520G>T, p.Asp174Tyr and D174Y, represents a rare variant in the GSN gene on chromosome 9. The minor allele, inherited in a dominant manner, is considered pathogenic in ClinVar for Meretoja syndrome, a form of familial amyloidosis. This mutation is considered a founder mutation among Finns.

A;G

see discussion at rs121909715

Source and license

Adapted from rs121909715 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.