rs121912762

A SNP in the RHD gene on chromosome 1. Its most notable genotype is C;C: Rh factor D(VII); see explanation

Gene
RHD
Location
Chr 125,284,753 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
AncestryDNA

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableBadRh factor D(VII); see explanationWorth knowing · 2.0
  2. C;TBadRh factor D(VII); see explanationWorth knowing · 2.0
  3. T;TGoodcommon in clinvarTypical · 0.0

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Other RHD SNPs

All RHD SNPs

Notes

From SNPedia

Notes

rs121912762, also known as Leu110Pro, represents an important SNP in the rhesus factor RHD gene. As reported in several publications, such as , the rs121912762(C) allele leads to a lack of epD8 and the expression of the low frequency antigen Rh40. The result of this a rare Rh-positive variant known as D(VII). RHD D(VII) individuals will be typed as Rh+, yet they can develop anti-D antibodies following immunization by pregnancy or transfusion. See also: OMIM 111680.0002

C;T

Will test as Rh-factor positive, yet may develop anti-D antibodies. See explanation at rs121912762.

Source and license

Adapted from rs121912762 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.