rs121913315
A SNP in the STK11 gene on chromosome 19. Its most notable genotype is A;G: STK11 gene mutation associated with Peutz-Jeghers syndrome
- Gene
- STK11
- Location
- Chr 191,220,488 (GRCh38)
- Highest magnitude
- 5.8Very important
- Tested on
- AncestryDNA
Genotypes
As shown in 23andMe and AncestryDNA files.
- A;GMost notableBadSTK11 gene mutation associated with Peutz-Jeghers syndrome
- G;GGoodcommon in clinvar
- G;TBadCutaneous malignant melanoma designation in Clinvar; cancer risk?
On SNPedia: (A;G), (G;G), (G;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Other STK11 SNPs
- rs9282859C;GSTK11 gene mutation associated with Peutz-Jeghers syndromeVery important
- rs121913321-;CSTK11 gene mutation associated with Peutz-Jeghers syndromeVery important
- rs121913322C;TSTK11 gene mutation associated with Peutz-Jeghers syndromeVery important
- rs121913324C;TSTK11 gene mutation associated with Peutz-Jeghers syndromeVery important
- rs137853075A;CLikely miscall in Ancestry v2c data; otherwise, STK11 gene mutation associated with Peutz-Jeghers syndromeVery important
- rs137853076A;TSTK11 gene mutation associated with Peutz-Jeghers syndromeVery important
- rs137853077C;TSTK11 gene mutation associated with Peutz-Jeghers syndromeVery important
- rs137853078A;GSTK11 gene mutation associated with Peutz-Jeghers syndromeVery important
Notes
From SNPedia
Notes
c.580G>T (p.Asp194Tyr) and also c.580G>A (p.Asp194Asn) 23andMe name for c.580G>T: i5006537
A;G
Very rare condition; false positives are possible.
G;T
Not listed as such in ClinVar, but possible PJS (or possible false positive)?
Source and license
Adapted from rs121913315 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.