rs121913626

A SNP in the MYH7 gene on chromosome 14. Its most notable genotype is C;G: Familial Hypertrophic Cardiomyopathy

Gene
MYH7
Location
Chr 1423,427,723 (GRCh38)
Highest magnitude
6.2Very important
Tested on
AncestryDNA

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. C;GMost notableBadFamilial Hypertrophic CardiomyopathyVery important · 6.2
  2. C;CGoodcommon in clinvarTypical · 0.0
  3. A;CBadFamilial Hypertrophic CardiomyopathyVery important · 6.2

SNPedia records rs121913626 on the minus strand: (C;G), (G;G), (G;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Conditions, medicines and genes

Other MYH7 SNPs

All MYH7 SNPs

Notes

From SNPedia

Notes

rs121913626, also known as c.1750G>C and p.Gly584Arg, is a mutation in the MYH7 gene considered to be an autosomal dominant leading to familial hypertrophic cardiomyopathy, according to multiple sources in ClinVar. This mutation was the fourth most common pathogenic variant seen in 2,912 unrelated individuals with nonsyndromic hypertrophic cardiomyopathy (HCM) presentations over a 10 year period (2004-2014) at the Partners Healthcare Personalized Medicine clinic in Boston. Note: 23andMe refers to this SNP as i6015303.

Source and license

Adapted from rs121913626 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.