rs3218713

A SNP in the MYH7 gene on chromosome 14. Its most notable genotype is A;C: Familial Hypertrophic Cardiomyopathy

Gene
MYH7
Location
Chr 1423,431,468 (GRCh38)
Highest magnitude
6.2Very important
Tested on
23andMe, AncestryDNA

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. T;TBadFamilial Hypertrophic CardiomyopathyVery important · 6.00% of people
  2. C;TBadFamilial Hypertrophic CardiomyopathyVery important · 6.00% of people
  3. C;CGoodcommon in clinvarTypical · 0.0100% of people
  4. A;CMost notableBadFamilial Hypertrophic CardiomyopathyVery important · 6.20% of people

SNPedia records rs3218713 on the minus strand: (A;A), (A;G), (G;G), (G;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 4 HapMap populations.

  • AverageT;T 0% C;T 0% C;C 100% A;C 0%
  • European ancestry (Utah)T;T 0% C;T 0% C;C 100% A;C 0%
  • Han Chinese (Beijing)T;T 0% C;T 0% C;C 100% A;C 0%
  • Japanese (Tokyo)T;T 0% C;T 0% C;C 100% A;C 0%
  • Yoruba (Nigeria)T;T 0% C;T 0% C;C 100% A;C 0%

Conditions, medicines and genes

Other MYH7 SNPs

All MYH7 SNPs

Notes

From SNPedia

Notes

The rare minor allele of this variant is reported to be pathogenic/likely pathogenic for familial hypertrophic cardiomyopathy (HCM), according to . see also OMIM 160760.0002

T;T

Familial hypertrophic cardiomyopathy see also OMIM 160760.0002

C;T

Familial hypertrophic cardiomyopathy see also OMIM 160760.0002

Source and license

Adapted from rs3218713 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.