rs121964856
A SNP in the TNNT2 gene on chromosome 1. Its most notable genotype is A;G: Hypertrophic Cardiomyopathy
- Gene
- TNNT2
- Location
- Chr 1201,365,297 (GRCh38)
- Highest magnitude
- 7.0Very important
- Tested on
- AncestryDNA
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
- C;TBadFamilial hypertrophic cardiomyopathy (possible)
- A;GMost notableBadHypertrophic Cardiomyopathy
- C;CGoodcommon in clinvar
SNPedia records rs121964856 on the minus strand: (A;G), (C;T), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Conditions, medicines and genes
Other TNNT2 SNPs
- rs74315379C;THypertrophic CardiomyopathyVery important
- rs45525839C;GDilated cardiomyopathyVery important
- rs111377893A;CFamilial Hypertrophic CardiomyopathyVery important
- rs121964858A;TFamilial Hypertrophic CardiomyopathyVery important
- rs376923877G;TFamilial Hypertrophic CardiomyopathyVery important
- rs397516454A;CDilated cardiomyopathyVery important
- rs397516456A;GFamilial Hypertrophic CardiomyopathyVery important
- rs397516461C;TDilated cardiomyopathyVery important
Notes
From SNPedia
Notes
The rare minor allele of this variant is reported to be pathogenic/likely pathogenic for familial hypertrophic cardiomyopathy (HCM), according to .
C;T
see discussion at rs121964856
A;G
see discussion and links via rs-page
Source and license
Adapted from rs121964856 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.