rs121964878
A SNP in the CDH1 gene on chromosome 16. Its most notable genotype is C;T: Hereditary cancer-predisposing syndrome; gastric cancer related?
- Gene
- CDH1
- Location
- Chr 1668,822,190 (GRCh38)
- Highest magnitude
- 5.0Very important
- Tested on
- AncestryDNA
Genotypes
As shown in 23andMe and AncestryDNA files.
- C;CGoodcommon in clinvar
- C;TMost notableBadHereditary cancer-predisposing syndrome; gastric cancer related?
On SNPedia: (C;C), (C;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Conditions, medicines and genes
Other CDH1 SNPs
- rs121964873G;TCDH1-based gastric cancer riskVery important
- rs121964874C;TCDH1-based gastric cancer riskVery important
- rs121964876G;TFalse positives possible; otherwise, Hereditary cancer-predisposing syndromeVery important
- rs121964877C;TCDH1-based gastric cancer riskVery important
- rs267606712A;GCDH1-based gastric cancer riskVery important
- rs587776398G;TCDH1-based gastric cancer riskVery important
- rs587780113A;GCDH1-based gastric cancer riskVery important
- rs587780784C;TCDH1-based gastric cancer riskVery important
Notes
From SNPedia
Notes
Also known as c.1901C>T, p.Ala634Val and A634V, the minor allele is considered a pathogenic rare mutation for hereditary diffuse gastric cancer in ClinVar.
C;T
see CDH1
Source and license
Adapted from rs121964878 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.