rs121964975
A SNP in the GLDC gene on chromosome 9. Its most notable genotype is -;-: Glycine encephalopathy; Non-ketotic hyperglycinemia
- Gene
- GLDC
- Location
- Chr 96,554,716 (GRCh38)
- Highest magnitude
- 8.8Very important
- Tested on
- AncestryDNA
Genotypes
As shown in 23andMe and AncestryDNA files.
- -;-Most notableBadGlycine encephalopathy; Non-ketotic hyperglycinemia
- -;TTCBadCarrier of a glycine encephalopathy mutation
- TCT;TCTGoodcommon in clinvar
On SNPedia: (-;-), (-;TTC), (TCT;TCT). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Other GLDC SNPs
- rs121964974A;AGlycine encephalopathy; Non-ketotic hyperglycinemiaVery important
- rs121964976G;GGlycine encephalopathy; Non-ketotic hyperglycinemiaVery important
- rs121964977A;AGlycine encephalopathy; Non-ketotic hyperglycinemiaVery important
- rs121964978G;GGlycine encephalopathy; Non-ketotic hyperglycinemiaVery important
- rs121964979A;AGlycine encephalopathy; Non-ketotic hyperglycinemiaVery important
- rs121964980T;TGlycine encephalopathy; Non-ketotic hyperglycinemiaVery important
- rs149070244G;GGlycine encephalopathy; Non-ketotic hyperglycinemiaVery important
- rs386833517A;AGlycine encephalopathy; Non-ketotic hyperglycinemiaVery important
Notes
From SNPedia
Notes
c.2267_2269delTCT (p.Phe756del)
-;-
see associated ClinVar and OMIM entries
-;TTC
Unaffected in absence of a second mutation in the GLDC gene
Source and license
Adapted from rs121964975 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.