rs121965064
A SNP in the F11 gene on chromosome 4. Its most notable genotype is C;C: Factor XI deficiency
- Gene
- F11
- Location
- Chr 4186,280,258 (GRCh38)
- Highest magnitude
- 5.0Very important
- Tested on
- 23andMe, AncestryDNA
Genotypes
As shown in 23andMe and AncestryDNA files.
- C;CMost notableBadFactor XI deficiency
- C;TBadcarrier of factor XI mutation
- T;TGoodcommon in clinvar
On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Other F11 SNPs
- rs28934608T;TFactor XI deficiencyVery important
- rs121965063T;TFactor XI deficiencyVery important
- rs121965066A;AFactor XI deficiencyVery important
- rs121965067A;AFactor XI deficiencyVery important
- rs121965068T;TFactor XI deficiencyVery important
- rs121965069C;CFactor XI deficiencyVery important
- rs121965071T;TFactor XI deficiencyVery important
- rs139695003T;TFactor XI deficiencyVery important
Notes
From SNPedia
Notes
rs121965064, also known as F283L or Phe283Leu, is a SNP in the coagulation factor XI F11 gene. This SNP is reported as one of the three most common factor XI-deficiency causing mutations in Ashkenazi Jews; it is reported as i4000399 by 23andMe.
C;T
Usually not affected in absence of a second F11 gene mutation
Source and license
Adapted from rs121965064 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.