rs12210050

A SNP in the LOC105374875 gene on chromosome 6. Its most notable genotype is C;T: Slightly higher risk for basal cell carcinoma

Gene
LOC105374875
Location
Chr 6475,489 (GRCh38)
Highest magnitude
1.5Minor
Tested on
23andMe, AncestryDNA
Minor allele frequency
6%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CGoodcommon on affy axiom dataTypical · 0.092% of people
  2. C;TMost notableBadSlightly higher risk for basal cell carcinomaMinor · 1.57% of people
  3. T;TBadSlighly higher risk for basal cell carcinomaMinor · 1.5<1% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 8 HapMap populations.

  • AverageC;C 92% C;T 7% T;T <1%
  • European ancestry (Utah)C;C 70% C;T 28% T;T 2%
  • Han Chinese (Beijing)C;C 100% C;T 0% T;T 0%
  • Japanese (Tokyo)C;C 100% C;T 0% T;T 0%
  • Yoruba (Nigeria)C;C 99% C;T 1% T;T 0%
  • African ancestry (Southwest US)C;C 93% C;T 5% T;T 2%
  • Gujarati IndianC;C 98% C;T 2% T;T 0%
  • Mexican ancestry (Los Angeles)C;C 95% C;T 5% T;T 0%
  • TuscanC;C 82% C;T 18% T;T 0%

Conditions, medicines and genes

Other LOC105374875 SNPs

All LOC105374875 SNPs

Notes

From SNPedia

Notes

rs12210050 was found to be associated with basal cell carcinoma based on a study by the eMERGE network in which electronic medical records were searched to find clinical associations associated with selected SNPs.

Source and license

Adapted from rs12210050 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.