rs12291063
A SNP in the BDNF gene on chromosome 11. Its most notable genotype is T;T: common genotype
- Gene
- BDNF
- Location
- Chr 1127,672,554 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
Genotypes
As shown in 23andMe and AncestryDNA files.
On SNPedia: (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 10 HapMap populations.
- AverageT;T 67%
- European ancestry (Utah)T;T 100%
- Han Chinese (Beijing)T;T 70%
- Japanese (Tokyo)T;T 67%
- Yoruba (Nigeria)T;T 38%
- African ancestry (Southwest US)T;T 54%
- Chinese (Denver)T;T 66%
- Gujarati IndianT;T 96%
- Luhya (Kenya)T;T 58%
- Mexican ancestry (Los Angeles)T;T 53%
- Maasai (Kenya)T;T 65%
Related
Other BDNF SNPs
- rs8192466A;AuncertainVery important
- rs6265T;Tintroversion; depression resistant; impaired motor skills learning; somewhat quicker mental decline in Alzheimer patientsWorth knowing
- rs988748C;GNo summary available.Typical
- rs11030104A;GNo summary available.Typical
- rs12273539C;Ccommon in complete genomicsTypical
Notes
From SNPedia
Show notes, about 120 words
Human Obesity Associated with an Intronic SNP in the Brain-Derived Neurotrophic Factor Locus. "We observed that the rs12291063 CC genotype was associated with lower expressions of BDNF transcripts ... and higher BMI and adiposity .... Our in vivo and clinical findings indicate that BDNF rs12291063, which had an MAF of ∼30% within our Hispanic and African-American cohorts, could play an important role in the pathogenesis of obesity in these populations. Mechanistically, our data suggest that diminished binding of hnRNPD0B at the rs12291063 locus in individuals with the CC genotype could cause decreased BDNF mRNA expression and protein concentrations within the hypothalamus, potentially leading to excessive energy intake and weight gain."
Source and license
Adapted from rs12291063 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.