rs8192466

A SNP in the BDNF gene on chromosome 11. Its most notable genotype is A;A: uncertain

Gene
BDNF
Location
Chr 1127,658,560 (GRCh38)
Highest magnitude
4.0Very important
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
<1%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. G;GGoodcommonTypical · 0.0100% of people
  2. A;GNot rateduncertain, probably harmlessWorth knowing · 2.5<1% of people
  3. A;AMost notableNot rateduncertainVery important · 4.00% of people

SNPedia records rs8192466 on the minus strand: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 5 HapMap populations.

  • AverageG;G 100% A;G <1% A;A 0%
  • European ancestry (Utah)G;G 100% A;G 0% A;A 0%
  • Han Chinese (Beijing)G;G 100% A;G 0% A;A 0%
  • Japanese (Tokyo)G;G 100% A;G 0% A;A 0%
  • Yoruba (Nigeria)G;G 100% A;G 0% A;A 0%
  • Mexican ancestry (Los Angeles)G;G 98% A;G 2% A;A 0%

Other BDNF SNPs

All BDNF SNPs

Notes

From SNPedia

Notes

A;G

according to ClinVar this is Pathogenic, and according to HapMap it's quite rare. However it seems to be occurring in quite a few Promethease reports from healthy people. We now suspect this is being incorrectly genotyped by 23andMe, but it remains uncertain

A;A

According to ClinVar this is Pathogenic for Congenital central hypoventilation, and according to HapMap it's quite rare. However The heterozygous form seems to be occurring in quite a few Promethease reports from healthy people. We now suspect this is being incorrectly genotyped by 23andMe, but it remains uncertain. If you've found it in your promethease report info@snpedia.com would like to hear from you.

Source and license

Adapted from rs8192466 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.