rs12340895(G;G)

2 - 4 fold increased odds of developing V617F-positive MPN

Magnitude
3.5Important
Repute
Bad
Frequency
5%Average of 11 populations
On SNPedia
rs12340895(G;G)
Gene
INSL6

Frequency

Share of people with G;G in each HapMap population.

  • Han Chinese (Beijing)8%
  • Mexican ancestry (Los Angeles)7%
  • Japanese (Tokyo)6%
  • European ancestry (Utah)6%
  • Gujarati Indian6%
  • Tuscan5%
  • Chinese (Denver)4%
  • Luhya (Kenya)4%
  • Maasai (Kenya)3%
  • African ancestry (Southwest US)2%
  • Yoruba (Nigeria)0%

Other genotypes of rs12340895

  1. C;CGoodNo summary available.Typical · 0.058% of people
  2. C;GBadIncreased odds (2 fold?) of developing V617F-positive MPNWorth knowing · 2.538% of people

All about rs12340895

Notes

From SNPedia

A Promethease user who has this rs12340895(G;G) genotype has reported that they have mastocytosis, a myeloproliferative neoplasm (MPN). But don't panic! Mastocytosis is listed as a rare disease by the Office of Rare Diseases (ORD) of the National Institutes of Health, which means mastocytosis affects less than 200,000 people in the entire US. To put it another way, 5 to 10 new cases are reported annually per million people. Since this rs12340895(G;G) genotype is carried by many people (e.g. ~10% of all Caucasians, or, over 30 million Americans), it's clear the overwhelming majority do not develop mastocytosis.

Source and license

Adapted from rs12340895(G;G) on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.