rs1243166
A SNP in the SERPINA1 gene on chromosome 14. Its most notable genotype is G;G: common/normal
- Gene
- SERPINA1
- Location
- Chr 1494,377,481 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
SNPedia records rs1243166 on the minus strand: (C;C), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageG;G 53% A;A 9%
- European ancestry (Utah)G;G 42% A;A 12%
- Han Chinese (Beijing)G;G 44% A;A 10%
- Japanese (Tokyo)G;G 40% A;A 14%
- Yoruba (Nigeria)G;G 64% A;A 3%
- African ancestry (Southwest US)G;G 63% A;A 5%
- Chinese (Denver)G;G 39% A;A 14%
- Gujarati IndianG;G 39% A;A 18%
- Luhya (Kenya)G;G 74% A;A 2%
- Mexican ancestry (Los Angeles)G;G 62% A;A 5%
- Maasai (Kenya)G;G 74% A;A 3%
- TuscanG;G 41% A;A 18%
Related
Other SERPINA1 SNPs
- rs28929474T;TAlpha-1 Antitrypsin DeficiencyVery important
- rs121912713A;CBleeding disorder likelyVery important
- rs267606950-;-Alpha1-anti-trypsin deficient homozygote; emphysema possibleVery important
- rs28931568T;Thigh risk of emphysema due to Alpha 1-Antitrypsin DeficiencyVery important
- rs28931569G;Ghigh risk of emphysemaVery important
- rs61761869A;APossible Alpha-1 Antrypsin deficiency genotypeImportant
- rs11558261C;Tcarrier for Alpha-1 Antitrypsin DeficiencyImportant
- rs28929472A;ANo summary available.Important
Source and license
Adapted from rs1243166 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.