rs61761869

A SNP in the SERPINA1 gene on chromosome 14. Its most notable genotype is A;A: Possible Alpha-1 Antrypsin deficiency genotype

Gene
SERPINA1
Location
Chr 1494,378,529 (GRCh38)
Highest magnitude
3.1Important
Tested on
23andMe, AncestryDNA

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableBadPossible Alpha-1 Antrypsin deficiency genotypeImportant · 3.1
  2. A;GBadLikely carrier of SERPINA1 mutation; slight chance of Alpha-1 Antitrypsin Deficiency?Worth knowing · 2.5
  3. G;GGoodcommon in clinvarTypical · 0.0

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Other SERPINA1 SNPs

All SERPINA1 SNPs

Notes

From SNPedia

Notes

c.1177C>A (p.Pro393Thr) Described as a pathogenic variant by a single lab (HerediLab) in ClinVar; not described elsewhere to our knowledge. If true, this would be considered an SERPINA1 genotype associated with alpha1-antitrypsin deficiency.

A;A

See rs61761869

A;G

Likely to be unaffected in absence of a second SERPINA1 mutation; the (A) allele is described as a pathogenic allele by (only) one submitter to ClinVar; see rs61761869

Source and license

Adapted from rs61761869 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.