rs12469063

A SNP in the MEIS1 gene on chromosome 2. Its most notable genotype is G;G: Increased risk of developing restless legs syndrome

Gene
MEIS1
Location
Chr 266,537,176 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
19%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AGoodNormal risk of developing restless legs syndromeMinor · 1.068% of people
  2. A;GBadSlightly increased risk of developing restless legs syndromeMinor · 1.529% of people
  3. G;GMost notableBadIncreased risk of developing restless legs syndromeWorth knowing · 2.03% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 68% A;G 29% G;G 3%
  • European ancestry (Utah)A;A 58% A;G 39% G;G 4%
  • Han Chinese (Beijing)A;A 56% A;G 40% G;G 4%
  • Japanese (Tokyo)A;A 55% A;G 43% G;G 3%
  • Yoruba (Nigeria)A;A 100% A;G 0% G;G 0%
  • African ancestry (Southwest US)A;A 90% A;G 11% G;G 0%
  • Chinese (Denver)A;A 52% A;G 40% G;G 8%
  • Gujarati IndianA;A 46% A;G 47% G;G 8%
  • Luhya (Kenya)A;A 98% A;G 2% G;G 0%
  • Mexican ancestry (Los Angeles)A;A 57% A;G 36% G;G 7%
  • Maasai (Kenya)A;A 89% A;G 12% G;G 0%
  • TuscanA;A 47% A;G 49% G;G 4%

Conditions, medicines and genes

Other MEIS1 SNPs

All MEIS1 SNPs

Genosets

Genosets combine several genotypes. Twofold checks them in your report.

Notes

From SNPedia

Notes

rs12469063, a SNP located in the MEIS1 gene, has been linked to restless legs syndrome, a common sleep disorder, with an overall odds ratio of 1.78 (CI: 1.52-2.10) for the (G) risk allele. The association from this region that gives the highest association to restless legs syndrome, however, is a haplotype consisting of the rs6710341(A) and rs12469063(G) alleles. This haplotype gives rise to an odds ratio of 2.75 (CI: 2.23-3.41). MEIS1 intronic risk haplotype associated with restless legs syndrome affects its mRNA and protein expression levels. Replication of restless legs syndrome loci in three European populations. Genotyping sleep disorders patients.

Source and license

Adapted from rs12469063 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.