rs6710341

A SNP in the MEIS1 gene on chromosome 2. Its most notable genotype is G;G: Increased risk of developing restless legs syndrome

Gene
MEIS1
Location
Chr 266,531,290 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
19%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AGoodNormal risk of developing restless legs syndromeMinor · 1.060% of people
  2. A;GBadSlightly increased risk of developing restless legs syndromeMinor · 1.536% of people
  3. G;GMost notableBadIncreased risk of developing restless legs syndromeWorth knowing · 2.04% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 60% A;G 36% G;G 4%
  • European ancestry (Utah)A;A 71% A;G 26% G;G 4%
  • Han Chinese (Beijing)A;A 56% A;G 41% G;G 4%
  • Japanese (Tokyo)A;A 55% A;G 43% G;G 3%
  • Yoruba (Nigeria)A;A 71% A;G 27% G;G 2%
  • African ancestry (Southwest US)A;A 56% A;G 42% G;G 2%
  • Chinese (Denver)A;A 52% A;G 39% G;G 8%
  • Gujarati IndianA;A 45% A;G 43% G;G 13%
  • Luhya (Kenya)A;A 68% A;G 30% G;G 2%
  • Mexican ancestry (Los Angeles)A;A 66% A;G 31% G;G 3%
  • Maasai (Kenya)A;A 61% A;G 33% G;G 6%
  • TuscanA;A 62% A;G 36% G;G 2%

Conditions, medicines and genes

Other MEIS1 SNPs

All MEIS1 SNPs

Genosets

Genosets combine several genotypes. Twofold checks them in your report.

Notes

From SNPedia

Notes

rs6710341, a SNP located in the MEIS1 gene, has been linked to restless legs syndrome, a common sleep disorder, with an overall odds ratio of 0.96 (CI: 0.77-1.17) for the (G) risk allele. The association from this region that gives the highest association to restless legs syndrome, however, is a haplotype consisting of the rs6710341(A) and rs12469063(G) alleles. This haplotype gives rise to an odds ratio of 2.75 (CI: 2.23-3.41).

Source and license

Adapted from rs6710341 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.