rs12476364
A SNP in the MSH2 gene on chromosome 2. Its most notable genotype is A;G: Lynch syndrome, pathogenic mutation
- Gene
- MSH2
- Location
- Chr 247,416,295 (GRCh38)
- Highest magnitude
- 6.0Very important
- Tested on
- AncestryDNA
Genotypes
As shown in 23andMe and AncestryDNA files.
- A;GMost notableBadLynch syndrome, pathogenic mutation
- C;GBadLynch syndrome, pathogenic mutation
- G;GGoodcommon in clinvar
- G;TBadLynch syndrome
On SNPedia: (A;G), (C;G), (G;G), (G;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 4 HapMap populations.
- AverageA;G 0% C;G 0% G;G 100% G;T 0%
- European ancestry (Utah)A;G 0% C;G 0% G;G 100% G;T 0%
- Han Chinese (Beijing)A;G 0% C;G 0% G;G 100% G;T 0%
- Japanese (Tokyo)A;G 0% C;G 0% G;G 100% G;T 0%
- Yoruba (Nigeria)A;G 0% C;G 0% G;G 100% G;T 0%
Related
Other MSH2 SNPs
- rs63750245T;TLynch syndrome; hereditary nonpolyposis colorectal cancer-1Very important
- rs63750875C;CLynch syndrome; hereditary nonpolyposis colorectal cancer (HNPCC1)Very important
- rs63751449-;-Lynch syndrome; hereditary nonpolyposis colorectal cancer-1Very important
- rs28929483C;TLynch syndrome, pathogenic mutationVery important
- rs28929484C;TLynch syndrome, pathogenic mutationVery important
- rs34986638G;TLynch syndrome, pathogenic mutationVery important
- rs63749802G;TLynch syndrome, pathogenic mutationVery important
- rs63749814-;GLynch syndrome, pathogenic mutationVery important
Source and license
Adapted from rs12476364 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.