rs63751449
A SNP in the MSH2 gene on chromosome 2. Its most notable genotype is -;-: Lynch syndrome; hereditary nonpolyposis colorectal cancer-1
- Gene
- MSH2
- Location
- Chr 247,410,181 (GRCh38)
- Highest magnitude
- 7.0Very important
- Tested on
- 23andMe
Genotypes
As shown in 23andMe and AncestryDNA files.
- -;-Most notableBadLynch syndrome; hereditary nonpolyposis colorectal cancer-1
- -;ABadLynch syndrome
- A;AGoodcommon in clinvar
- I;IGoodNo summary available.
On SNPedia: (-;-), (-;A), (A;A), (I;I). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Conditions, medicines and genes
Other MSH2 SNPs
- rs63750245T;TLynch syndrome; hereditary nonpolyposis colorectal cancer-1Very important
- rs63750875C;CLynch syndrome; hereditary nonpolyposis colorectal cancer (HNPCC1)Very important
- rs12476364A;GLynch syndrome, pathogenic mutationVery important
- rs28929483C;TLynch syndrome, pathogenic mutationVery important
- rs28929484C;TLynch syndrome, pathogenic mutationVery important
- rs34986638G;TLynch syndrome, pathogenic mutationVery important
- rs63749802G;TLynch syndrome, pathogenic mutationVery important
- rs63749814-;GLynch syndrome, pathogenic mutationVery important
Notes
From SNPedia
Notes
rs63751449 is a SNP in the MSH2 gene on chromosome 2, associated with Lynch syndrome (HNPCC). This variant meets the criteria published in 2013 by the ACMG regarding incidental findings in exome or genome sequencing, as a variant that they do recommend informing a patient about. See also OMIM 609309.0016
-;-
Lynch syndrome; hereditary nonpolyposis colorectal cancer-1
Source and license
Adapted from rs63751449 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.