rs12484776

A SNP in the TNRC6B gene on chromosome 22. Its most notable genotype is A;A: Normal Risk of UF for Japanese

Gene
TNRC6B
Location
Chr 2240,256,869 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
23%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableGoodNormal Risk of UF for JapaneseTypical · 0.064% of people
  2. A;GBad1.23 Risk of UF for Japanese for G AlleleTypical · 0.031% of people
  3. G;GBad>1.23 Risk of UF for Japanese for G AlleleTypical · 0.06% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 64% A;G 31% G;G 6%
  • European ancestry (Utah)A;A 59% A;G 37% G;G 4%
  • Han Chinese (Beijing)A;A 56% A;G 40% G;G 4%
  • Japanese (Tokyo)A;A 30% A;G 56% G;G 14%
  • Yoruba (Nigeria)A;A 89% A;G 10% G;G 1%
  • African ancestry (Southwest US)A;A 79% A;G 18% G;G 4%
  • Chinese (Denver)A;A 57% A;G 39% G;G 4%
  • Gujarati IndianA;A 58% A;G 36% G;G 6%
  • Luhya (Kenya)A;A 92% A;G 8% G;G 0%
  • Mexican ancestry (Los Angeles)A;A 17% A;G 60% G;G 22%
  • Maasai (Kenya)A;A 83% A;G 15% G;G 1%
  • TuscanA;A 78% A;G 21% G;G 1%

Other TNRC6B SNPs

All TNRC6B SNPs

Notes

From SNPedia

Notes

A genome-wide association study identifies three loci associated with susceptibility to uterine fibroids in Japanese

Source and license

Adapted from rs12484776 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.