rs9623117

A SNP in the TNRC6B gene on chromosome 22. Its most notable genotype is C;C: 1.1x increased risk for prostate cancer

Gene
TNRC6B
Location
Chr 2240,056,115 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA
Minor allele frequency
31%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableBad1.1x increased risk for prostate cancerTypical · 0.026% of people
  2. C;TBad1.1x increased risk for prostate cancerTypical · 0.026% of people
  3. T;TNot ratednormalTypical · 0.048% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 26% C;T 26% T;T 48%
  • European ancestry (Utah)C;C 4% C;T 37% T;T 59%
  • Han Chinese (Beijing)C;C <1% C;T 7% T;T 93%
  • Japanese (Tokyo)C;C 0% C;T 4% T;T 96%
  • Yoruba (Nigeria)C;C 83% C;T 16% T;T <1%
  • African ancestry (Southwest US)C;C 39% C;T 49% T;T 12%
  • Chinese (Denver)C;C 0% C;T 4% T;T 96%
  • Gujarati IndianC;C 9% C;T 55% T;T 37%
  • Luhya (Kenya)C;C 86% C;T 14% T;T <1%
  • Mexican ancestry (Los Angeles)C;C 0% C;T 28% T;T 72%
  • Maasai (Kenya)C;C 56% C;T 40% T;T 5%
  • TuscanC;C 7% C;T 34% T;T 59%

Conditions, medicines and genes

Other TNRC6B SNPs

All TNRC6B SNPs

Notes

From SNPedia

Notes

In seven different populations studied, rs9623117(C) was consistently higher in aggressive prostate cancer cases than in controls (p = 5.0 x 10e-7). The odds ratio (OR) of allele C for aggressive prostate cancer was estimated to be 1.18 (CI: 1.11-1.26). This SNP was also associated with increased risk for nonaggressive prostate cancer, with an odds ratio of 1.11 (CI: 1.04 - 1.19, p = 0.004).

Source and license

Adapted from rs9623117 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.