rs1293789661
A SNP in the CLCN2 gene on chromosome 3. Its most notable genotype is C;T: Familial hyperaldosteronism type 2 mutation
- Gene
- CLCN2
- Location
- Chr 3184,359,124 (GRCh38)
- Highest magnitude
- 6.0Very important
- Tested on
- Not on consumer chips
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
- C;TMost notableBadFamilial hyperaldosteronism type 2 mutation
- C;CGoodcommon/normal
SNPedia records rs1293789661 on the minus strand: (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Other CLCN2 SNPs
- rs758379595A;TFamilial hyperaldosteronism type 2 mutationVery important
- rs1085307938C;TFamilial hyperaldosteronism type 2 mutationVery important
- rs1553853557G;TFamilial hyperaldosteronism type 2 mutationVery important
- rs1553856214A;TFamilial hyperaldosteronism type 2 mutationVery important
- rs1553857113A;TFamilial hyperaldosteronism type 2 mutationVery important
Notes
From SNPedia
Notes
aka c.515G>A (p.Arg172Gln or R172Q) see also OMIM 600570.0010
C;T
Hypertension and possible kidney disease are associated with hyperaldosteronism; considered to be a dominant mutation (see links via main rs-page)
Source and license
Adapted from rs1293789661 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.