rs1303
A SNP in the SERPINA1 gene on chromosome 14. Its most notable genotype is T;T: common in clinvar
- Gene
- SERPINA1
- Location
- Chr 1494,378,506 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, AncestryDNA
- Minor allele frequency
- 23%
Genotypes
As shown in 23andMe and AncestryDNA files.
On SNPedia: (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageT;T 61%
- European ancestry (Utah)T;T 49%
- Han Chinese (Beijing)T;T 50%
- Japanese (Tokyo)T;T 50%
- Yoruba (Nigeria)T;T 83%
- African ancestry (Southwest US)T;T 81%
- Chinese (Denver)T;T 50%
- Gujarati IndianT;T 32%
- Luhya (Kenya)T;T 94%
- Mexican ancestry (Los Angeles)T;T 47%
- Maasai (Kenya)T;T 80%
- TuscanT;T 62%
Related
Other SERPINA1 SNPs
- rs28929474T;TAlpha-1 Antitrypsin DeficiencyVery important
- rs121912713A;CBleeding disorder likelyVery important
- rs267606950-;-Alpha1-anti-trypsin deficient homozygote; emphysema possibleVery important
- rs28931568T;Thigh risk of emphysema due to Alpha 1-Antitrypsin DeficiencyVery important
- rs28931569G;Ghigh risk of emphysemaVery important
- rs61761869A;APossible Alpha-1 Antrypsin deficiency genotypeImportant
- rs11558261C;Tcarrier for Alpha-1 Antitrypsin DeficiencyImportant
- rs28929472A;ANo summary available.Important
Notes
From SNPedia
Notes
finds no association between rs1303 and pulmonary emphysema
Source and license
Adapted from rs1303 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.