rs137852749
A SNP in the BMPR2 gene on chromosome 2. Its most notable genotype is A;G: Pulmonary arterial hypertension
- Gene
- BMPR2
- Location
- Chr 2202,552,774 (GRCh38)
- Highest magnitude
- 6.2Very important
- Tested on
- AncestryDNA
Genotypes
As shown in 23andMe and AncestryDNA files.
- A;GMost notableBadPulmonary arterial hypertension
- G;GGoodcommon in clinvar
On SNPedia: (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Other BMPR2 SNPs
- rs137852741C;TPulmonary arterial hypertensionVery important
- rs137852742C;GPulmonary arterial hypertensionVery important
- rs137852743G;TPulmonary arterial hypertensionVery important
- rs137852744A;GPulmonary arterial hypertensionVery important
- rs137852745A;GPulmonary arterial hypertensionVery important
- rs137852746C;TPulmonary arterial hypertensionVery important
- rs137852747A;CPulmonary arterial hypertensionVery important
- rs137852748C;TPulmonary arterial hypertensionVery important
Notes
From SNPedia
Notes
aka c.1472G>A (p.Arg491Gln) Known to have reduced penetrance; a 2019 article suggests that as-yet-unidentified variants in a nearby gene, FIGN, may be needed to bring about pulmonary arterial hypertension. 23andMe name: i5005635
Source and license
Adapted from rs137852749 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.