rs137853583

A SNP in the GPI gene on chromosome 19. Its most notable genotype is A;A: Hemolytic anemia due to GPI deficiency

Gene
GPI
Location
Chr 1934,394,044 (GRCh38)
Highest magnitude
6.7Very important
Tested on
23andMe, AncestryDNA

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableBadHemolytic anemia due to GPI deficiencyVery important · 6.7
  2. A;GBadCarrier of hemolytic anemia mutationImportant · 3.0
  3. G;GGoodcommon in clinvarTypical · 0.0

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Notes

From SNPedia

Notes

GPI gene,c.1040G>A, p.Arg347His or R347H variant, considered a causative mutation for Hemolytic anemia (hemolysis) when inherited recessively. See ClinVar, OMIM &

A;A

see rs137853583

A;G

Unaffected in absence of a second GPI gene mutation; see rs137853583

Source and license

Adapted from rs137853583 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.