rs137853822

A SNP in the GNPTAB gene on chromosome 12. Its most notable genotype is A;C: possible association with stuttering

Gene
GNPTAB
Location
Chr 12101,768,082 (GRCh38)
Highest magnitude
2.9Worth knowing
Tested on
Not on consumer chips

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. C;CGoodcommon/normalTypical · 0.0
  2. A;CMost notableBadpossible association with stutteringWorth knowing · 2.9
  3. A;ABadpossible association with stutteringWorth knowing · 2.9

SNPedia records rs137853822 on the minus strand: (G;G), (G;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Conditions, medicines and genes

Other GNPTAB SNPs

All GNPTAB SNPs

Notes

From SNPedia

Notes

rs137853822, also known as c.1363G>T, Ala455Ser or A455S, is a variant in the GNPTAB gene on chromosome 12. The minor (T) allele of rs137853822 was a mutation in the GNPTAB gene associated with stuttering in a 2010 study. Note that inheritance was neither dominant or recessive; this variant increased the risk of stuttering when present in either one or two copies, consistent with an additive genetic effect. Female homozygotes were apparently less affected. Note that the proportion of stutterers likely to carry a GNPTAB variant is likely to be less than 4%.

A;C

see discussion at rs137853822

A;A

see discussion at rs137853822

Source and license

Adapted from rs137853822 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.