rs137853825
A SNP in the GNPTAB gene on chromosome 12. Its most notable genotype is T;T: possible association with stuttering
- Gene
- GNPTAB
- Location
- Chr 12101,753,376 (GRCh38)
- Highest magnitude
- 2.9Worth knowing
- Tested on
- AncestryDNA
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
- T;TMost notableBadpossible association with stuttering
- C;TBadpossible association with stuttering
- C;CGoodcommon/normal
SNPedia records rs137853825 on the minus strand: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Conditions, medicines and genes
Notes
From SNPedia
Show notes, about 150 words
rs137853825, also known as c.3598G>A, Glu1200Lys or E1200K, is a variant in the GNPTAB gene on chromosome 12. The minor (A) allele of rs137853825 was the most common of several mutations in the GNPTAB gene associated with stuttering in a 2010 study. Note that inheritance was neither dominant or recessive; this variant increased the risk of stuttering when present in either one or two copies, consistent with an additive genetic effect. Female homozygotes were apparently less affected. Note that the proportion of stutterers likely to carry a GNPTAB variant is likely to be less than 4%. In 2016, 3- to 8-day old mice pups engineered to carry two copies of the Glu1200Lys mutation were observed to have significantly longer pauses in their spontaneous vocalizations than littermates not carrying the mutations, consistent with some features of human stuttering.
T;T
see discussion at rs137853825
C;T
see discussion at rs137853825
Source and license
Adapted from rs137853825 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.