rs138726443
A SNP in the FLG gene on chromosome 1. Its most notable genotype is A;G: Ichthyosis vulgaris (dry, scaly skin)
- Gene
- FLG
- Location
- Chr 1152,307,547 (GRCh38)
- Highest magnitude
- 4.0Very important
- Tested on
- AncestryDNA
Genotypes
As shown in 23andMe and AncestryDNA files.
- A;GMost notableBadIchthyosis vulgaris (dry, scaly skin)
- G;GGoodcommon in clinvar
On SNPedia: (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Conditions, medicines and genes
Other FLG SNPs
- rs121909626C;GIchthyosis vulgaris (dry, scaly skin)Very important
- rs141784184G;TIchthyosis vulgaris (dry, scaly skin)Very important
- rs150597413G;TIchthyosis vulgaris (dry, scaly skin)Very important
- rs535289422A;GIchthyosis vulgaris (dry, scaly skin)Very important
- rs754812742G;TIchthyosis vulgaris (dry, scaly skin)Very important
- rs761212672G;TIchthyosis vulgaris (dry, scaly skin)Very important
- rs797045090A;GIchthyosis vulgaris (dry, scaly skin)Very important
- rs1060499587-;ACAGGIchthyosis vulgaris (dry, scaly skin)Very important
Notes
From SNPedia
Notes
aka c.7339C>T (p.Arg2447Ter or R2447X) Dominantly inherited variant pathogenic for ichthyosis vulgaris in ClinVar, and also associated with higher odds of eczema (OR 1.96, CI:1.69-2.27).
A;G
see text and links via main rs-page
Source and license
Adapted from rs138726443 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.