rs140474226
A SNP in the DSP gene on chromosome 6. Its most notable genotype is C;T: Several cardiac conditions reported/predicted
- Gene
- DSP
- Location
- Chr 67,580,370 (GRCh38)
- Highest magnitude
- 6.1Very important
- Tested on
- 23andMe, AncestryDNA
Genotypes
As shown in 23andMe and AncestryDNA files.
- C;CGoodcommon in clinvar
- C;TMost notableBadSeveral cardiac conditions reported/predicted
On SNPedia: (C;C), (C;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Conditions, medicines and genes
Other DSP SNPs
- rs121912999A;GArrhythmogenic right ventricular dysplasiaVery important
- rs397516919A;GArrhythmogenic right ventricular dysplasiaVery important
- rs397516923C;TArrhythmogenic right ventricular dysplasiaVery important
- rs397516929C;TArrhythmogenic right ventricular dysplasiaVery important
- rs397516933C;TArrhythmogenic right ventricular dysplasiaVery important
- rs397516946C;TArrhythmogenic right ventricular dysplasiaVery important
- rs727502993-;ACArrhythmogenic right ventricular dysplasiaVery important
- rs727503000-;AArrhythmogenic right ventricular dysplasiaVery important
Notes
From SNPedia
Notes
aka c.4180C>T (p.Gln1394Ter) Reported in ClinVar as pathogenic for dilated cardiomyopathy and likely pathogenic for arrhythmogenic right ventricular dysplasia; also reported in a sudden cardiac death patient
C;T
see text and links via main rs-page
Source and license
Adapted from rs140474226 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.