rs140603

A SNP in the FBN1 gene on chromosome 15. Its most notable genotype is C;G: Familial thoracic aortic aneurysms and dissections (FTAAD)

Gene
FBN1
Location
Chr 1548,503,845 (GRCh38)
Highest magnitude
6.5Very important
Tested on
AncestryDNA
Minor allele frequency
<1%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. G;GGoodcommon in clinvarTypical · 0.099% of people
  2. C;GMost notableBadFamilial thoracic aortic aneurysms and dissections (FTAAD)Very important · 6.50% of people

SNPedia records rs140603 on the minus strand: (C;C), (C;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 6 HapMap populations.

  • AverageG;G 99% C;G 0%
  • European ancestry (Utah)G;G 100% C;G 0%
  • Han Chinese (Beijing)G;G 100% C;G 0%
  • Japanese (Tokyo)G;G 100% C;G 0%
  • Yoruba (Nigeria)G;G 97% C;G 0%
  • African ancestry (Southwest US)G;G 98% C;G 0%
  • Luhya (Kenya)G;G 97% C;G 0%

Other FBN1 SNPs

All FBN1 SNPs

Source and license

Adapted from rs140603 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.