rs140630

A SNP in the FBN1 gene on chromosome 15. Its most notable genotype is A;G: Familial thoracic aortic aneurysms and dissections (FTAAD)

Gene
FBN1
Location
Chr 1548,465,580 (GRCh38)
Highest magnitude
6.5Very important
Tested on
23andMe, AncestryDNA

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. G;GGoodcommon in clinvarTypical · 0.099% of people
  2. A;GMost notableBadFamilial thoracic aortic aneurysms and dissections (FTAAD)Very important · 6.51% of people

SNPedia records rs140630 on the minus strand: (C;C), (C;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 7 HapMap populations.

  • AverageG;G 99% A;G 1%
  • European ancestry (Utah)G;G 100% A;G 0%
  • Han Chinese (Beijing)G;G 99% A;G 2%
  • Japanese (Tokyo)G;G 99% A;G <1%
  • Yoruba (Nigeria)G;G 99% A;G <1%
  • Gujarati IndianG;G 99% A;G 1%
  • Luhya (Kenya)G;G 99% A;G <1%
  • Mexican ancestry (Los Angeles)G;G 97% A;G 4%

Other FBN1 SNPs

All FBN1 SNPs

Source and license

Adapted from rs140630 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.