rs141542003

A SNP in the TMEM126B gene on chromosome 11. Its most notable genotype is G;T: Carrier of a mitochondrial disorder mutation (Complex I deficiency)

Gene
TMEM126B
Location
Chr 1185,636,171 (GRCh38)
Highest magnitude
3.0Important
Tested on
AncestryDNA

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. G;GGoodcommon in clinvarTypical · 0.0
  2. G;TMost notableBadCarrier of a mitochondrial disorder mutation (Complex I deficiency)Important · 3.0

On SNPedia: (G;G), (G;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Other TMEM126B SNPs

All TMEM126B SNPs

Notes

From SNPedia

Notes

Biallelic Mutations in TMEM126B Cause Severe Complex I Deficiency with a Variable Clinical Phenotype

G;T

Unaffected in absence of another TMEM126B gene mutation.

Source and license

Adapted from rs141542003 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.