rs142150953

A SNP in the MOCOS gene on chromosome 18. Its most notable genotype is T;T: Xanthinuria type 2

Gene
MOCOS
Location
Chr 1836,213,402 (GRCh38)
Highest magnitude
4.5Very important
Tested on
AncestryDNA

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CGoodcommon/normalTypical · 0.0
  2. C;TBadCarrier of a pathogenic mutation for Xanthinuria type 2Important · 3.0
  3. T;TMost notableBadXanthinuria type 2Very important · 4.5

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Notes

From SNPedia

Notes

MOCOS gene, c.1255C>T (p.Arg419Ter) Minor allele is reported in ClinVar as pathogenic for Xanthinuria type 2

C;T

Unaffected unless carrying another pathogenic mutation in the MOCOS gene

T;T

Variable age of onset; see discussion

Source and license

Adapted from rs142150953 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.