rs142698837
A SNP in the TG gene on chromosome 8. Its most notable genotype is A;A: Possible association with thyroid dyshormonogenesis
- Gene
- TG
- Location
- Chr 8132,869,781 (GRCh38)
- Highest magnitude
- 3.0Important
- Tested on
- Not on consumer chips
Genotypes
As shown in 23andMe and AncestryDNA files.
- A;AMost notableBadPossible association with thyroid dyshormonogenesis
- A;GBadPossible association with thyroid dyshormonogenesis
- G;GGoodcommon/normal
On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Other TG SNPs
- rs180223G;T1.3x to 11.5x Increased risk of autoimmune thyroid diseaseWorth knowing
- rs2076740C;C2.4-6.1 risk of Autoimmune thyroid disease, if other SNP risk alleles presentWorth knowing
- rs2069550T;Tcommon in clinvarTypical
- rs2069556A;Acommon in clinvarTypical
- rs2069561G;Gcommon in clinvarTypical
- rs2229843G;Gcommon in complete genomicsTypical
- rs16904774G;Gcommon in clinvarTypical
Notes
From SNPedia
Notes
c.229G>A, p.Gly77Ser, G77S ClinVar indicated "uncertain significance" for a form of thyroid dyshormonogenesis, listed in OMIM as a recessively inherited condition; in , this variant appears to have some effect even if inherited in only one copy (see paper for discussion) and so is considered pathogenic.
A;A
see discussion and links via main rs-page
A;G
see discussion and links via main rs-page
Source and license
Adapted from rs142698837 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.