rs142991475
A SNP in the FLG gene on chromosome 1. Its most notable genotype is G;G: common in clinvar
- Gene
- FLG
- Location
- Chr 1152,313,823 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, AncestryDNA
Genotypes
As shown in 23andMe and AncestryDNA files.
On SNPedia: (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Other FLG SNPs
- rs121909626C;GIchthyosis vulgaris (dry, scaly skin)Very important
- rs138726443A;GIchthyosis vulgaris (dry, scaly skin)Very important
- rs141784184G;TIchthyosis vulgaris (dry, scaly skin)Very important
- rs150597413G;TIchthyosis vulgaris (dry, scaly skin)Very important
- rs535289422A;GIchthyosis vulgaris (dry, scaly skin)Very important
- rs754812742G;TIchthyosis vulgaris (dry, scaly skin)Very important
- rs761212672G;TIchthyosis vulgaris (dry, scaly skin)Very important
- rs797045090A;GIchthyosis vulgaris (dry, scaly skin)Very important
Notes
From SNPedia
Notes
The Q355X pathogenic variant in the FLG gene has not been reported previously as a pathogenic variant nor as a benign variant, to our knowledge. This variant is predicted to cause loss of normal protein function through protein truncation. The Q355X variant was not observed in the homozgyous state or at any significant frequency in approximately 6500 individuals of European and African American ancestry by the NHLBI Exome Sequencing Project. We interpret Q355X as a pathogenic variant. ncbi.nlm.nih.gov
Source and license
Adapted from rs142991475 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.