rs144567652

A SNP in the FANCM gene on chromosome 14. Its most notable genotype is C;T: ~3x higher breast cancer risk

Gene
FANCM
Location
Chr 1445,198,718 (GRCh38)
Highest magnitude
3.0Important
Tested on
23andMe

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CGoodcommon/normalTypical · 0.0
  2. C;TMost notableBad~3x higher breast cancer riskImportant · 3.0

On SNPedia: (C;C), (C;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Conditions, medicines and genes

Notes

From SNPedia

Notes

rs144567652, also known as c.5791C>T, p.Arg1931Ter and R1931X, is a SNP in the FANCM gene. Genotyping 8,635 familial breast cancer cases led to an association with rs144567652, (odds ratio 3.93, CI:1.28-12.11, p=0.017), and two subsequent meta-analyses showed similar [breast cancer]] associations (odds ratio 3.67, CI:1.04-12.87, p=0.043, and, OR of 3.33, CI:1.09-13.62, p=0.032), respectively. Note: a name used by 23andMe for this SNP is i6050899.

C;T

See discussion at rs144567652.

Source and license

Adapted from rs144567652 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.