rs146795505

A SNP in the ORC6 gene on chromosome 16. Its most notable genotype is C;C: Meier-Gorlin syndrome 3

Gene
ORC6
Location
Chr 1646,689,707 (GRCh38)
Highest magnitude
7.5Very important
Tested on
AncestryDNA

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableBadMeier-Gorlin syndrome 3Very important · 7.5
  2. C;TBadCarrier of a pathogenic mutation for Meier-Gorlin syndrome 3Important · 3.0
  3. T;TGoodcommon/normalTypical · 0.0

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Conditions, medicines and genes

Notes

From SNPedia

Notes

ORC6 gene, c.2T>C (p.Met1Thr) The minor allele is reported in ClinVar as pathogenic for Meier-Gorlin syndrome 3, apparently based on a single report; the condition is normally recessively inherited.

C;C

See discussion

C;T

Unaffected unless carrying another pathogenic mutation in the ORC6 gene

Source and license

Adapted from rs146795505 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.