rs147077598

A SNP in the DARS gene on chromosome 2. Its most notable genotype is C;C: likely hypomyelination with brainstem and spinal cord involvement and leg spasticity

Gene
DARS
Location
Chr 2135,907,342 (GRCh38)
Highest magnitude
5.0Very important
Tested on
AncestryDNA

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableBadlikely hypomyelination with brainstem and spinal cord involvement and leg spasticityVery important · 5.0
  2. C;GBadunaffected carrier of rare mutationImportant · 3.0
  3. G;GGoodcommonTypical · 0.0

On SNPedia: (C;C), (C;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Other DARS SNPs

All DARS SNPs

Notes

From SNPedia

Notes

Rare mutation leading (when present in two copies or in addition to another mutation) to hypomyelination with brainstem and spinal cord involvement and leg spasticity. See also: OMIM 603084

C;C

Be aware of potential for ambiguous flips (i.e. orientation issues) with this SNP. Contact SNPedia if your data indicates you are a (C;C) genotype.

Source and license

Adapted from rs147077598 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.