rs149019598

A SNP in the SRRM2 gene on chromosome 16. Its most notable genotype is C;T: higher risk for papillary thyroid carcinoma

Gene
SRRM2
Location
Chr 162,761,565 (GRCh38)
Highest magnitude
3.0Important
Tested on
Not on consumer chips

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CGoodcommon/normalTypical · 0.0
  2. C;TMost notableBadhigher risk for papillary thyroid carcinomaImportant · 3.0

On SNPedia: (C;C), (C;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Notes

From SNPedia

Notes

Papillary thyroid carcinoma (PTC) patients were genotyped and sequenced, and a mutation in the SRRM2 gene co-segregated with the disease in some but not all families - rs149019598, also known as c.1037C > T, Ser346Phe and S346F.

C;T

see discussion at rs149019598

Source and license

Adapted from rs149019598 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.