rs15251
A SNP in the TCOF1 gene on chromosome 5. Its most notable genotype is C;C: common in clinvar
- Gene
- TCOF1
- Location
- Chr 5150,396,669 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, AncestryDNA
- Minor allele frequency
- 21%
Genotypes
As shown in 23andMe and AncestryDNA files.
On SNPedia: (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageC;C 66%
- European ancestry (Utah)C;C 57%
- Han Chinese (Beijing)C;C 64%
- Japanese (Tokyo)C;C 64%
- Yoruba (Nigeria)C;C 93%
- African ancestry (Southwest US)C;C 83%
- Chinese (Denver)C;C 67%
- Gujarati IndianC;C 34%
- Luhya (Kenya)C;C 90%
- Mexican ancestry (Los Angeles)C;C 57%
- Maasai (Kenya)C;C 85%
- TuscanC;C 35%
Related
Other TCOF1 SNPs
- rs28941769A;GTreacher Collins syndrome, type 1 (predicted)Very important
- rs119470016C;TTreacher Collins syndrome, type 1 (predicted)Very important
- rs119470017C;TTreacher Collins syndrome, type 1 (predicted)Very important
- rs587776580-;ATreacher Collins syndrome, type 1 (predicted)Very important
- rs587776581-;ATACTreacher Collins syndrome, type 1 (predicted)Very important
- rs587776582-;AAGAATreacher Collins syndrome, type 1 (predicted)Very important
- rs587776583-;AGTreacher Collins syndrome, type 1 (predicted)Very important
- rs587776584-;AAGGTGAGTGGGACTGCCTreacher Collins syndrome, type 1 (predicted)Very important
Notes
From SNPedia
Notes
rs2255796 and rs15251 suggested excess maternal transmission and may influence risk of cleft palate
Source and license
Adapted from rs15251 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.