rs1545985

A SNP in the FYCO1 gene on chromosome 3. Its most notable genotype is A;A: normal risk

Gene
FYCO1
Location
Chr 345,963,986 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
19%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableNot ratednormal riskTypical · 0.069% of people
  2. A;GBadsomewhat higher risk for prostate cancerTypical · 0.025% of people
  3. G;GBadsomewhat higher risk for prostate cancerTypical · 0.06% of people
  4. T;TNot ratedNo summary available.Typical · 0.00% of people

On SNPedia: (A;A), (A;G), (G;G), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 69% A;G 25% G;G 6% T;T 0%
  • European ancestry (Utah)A;A 43% A;G 39% G;G 18% T;T 0%
  • Han Chinese (Beijing)A;A 99% A;G <1% G;G 0% T;T 0%
  • Japanese (Tokyo)A;A 100% A;G 0% G;G 0% T;T 0%
  • Yoruba (Nigeria)A;A 74% A;G 24% G;G 2% T;T 0%
  • African ancestry (Southwest US)A;A 61% A;G 35% G;G 4% T;T 0%
  • Chinese (Denver)A;A 99% A;G <1% G;G 0% T;T 0%
  • Gujarati IndianA;A 30% A;G 50% G;G 21% T;T 0%
  • Luhya (Kenya)A;A 63% A;G 33% G;G 5% T;T 0%
  • Mexican ancestry (Los Angeles)A;A 79% A;G 19% G;G 2% T;T 0%
  • Maasai (Kenya)A;A 55% A;G 36% G;G 9% T;T 0%
  • TuscanA;A 54% A;G 38% G;G 8% T;T 0%

Conditions, medicines and genes

Other FYCO1 SNPs

All FYCO1 SNPs

Notes

From SNPedia

Notes

rs1545985 is one of seven SNPs found in a combined study of over 1,000 patients to be associated with increased risk for prostate cancer. The risk allele for this SNP is (G); and while the odds ratio was not specifically reported, the probability of false significance (not permuted though) was given as p=6.6 x 10e-6, using an additive model of risk.

Source and license

Adapted from rs1545985 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.